Fractures and controlled hypoxia

Angiogenesis (formation of blood vessels) is a key process in the course of merging fracture. Disorders in the development of fractures within the vasculature, in addition to complications discussed in the introduction, the lead to the development of acidosis (lowering of pH). The low level of pH at the site of bone interferes confluent angiogenesis, which is mainly stimulated by osteoblasts. While in terms of simulated altitude of disorders that can be prevented in two ways.

At the begining of your stay at a simulated altitude of 3500 m above sea level (altitude range is large) normobarii under a reduced oxygen reaches the breathing and heart rate acceleration. It is also an excellent form of rehabilitation, because such a response on the part of the respiratory and circulatory corresponds to physical exertion. Tachypnea is one more crucial in the case of fractures. This leads to increase in pH, which combats lactic perfectly at the fracture site. Thanks to this factor by osteoblasts stimulated the development of new blood vessels is not weakened.

 

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The factor responsible for the development of new blood vessels within the fracture factor called vascular endothelial growth (VEGF). This is one of the factors whose activity is increased in response to the adaptation to the altitude. The whole cascade of adaptive mechanisms is triggered by hypoxia-inducible factor (HIF). Enhances the activity of VEGF, especially in the most hypoxic, which in the case of a fracture nonunion fracture site (Spector JA. 2000).The simultaneous increase in erythropoietin changes the rheological properties of blood, making it easier to reach areas affected by trauma and nourishes them better. Erythropoietin itself has anti-inflammatory properties.

 

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Additionally, it was observed that after conditioning in altitude conditions occur within the osteoblast activity to increase the concentration of insulin-like growth factor – 2 (IGF-2), which is one of the essential growth factors, so thus accelerates the regeneration of bone (Steinbrech DS. 2000).

Such a body’s response to high altitude conditions means that the area covered by the trauma is healed much faster, while respiratory and circulatory rehabilitation, so that the loss of physical fitness is much smaller. To achieve this, sufficient short-term stays (1-2 hours) in terms of lifting, and the consequent stay in „normal” conditions will allow the body to 100% oxygen utilization and accelerate tissue regeneration.