Cardiovascular diseases – sign of the times

According to the World Health Organization (WHO), cardiovascular diseases are the leading cause of death in developed countries. Hypertension has become almost a common disease, and myocardial infarctions affecting younger and younger people. At the attitudes of the problem is the increasing alienation of man from nature:

  • consumption of highly processed foods,
  • lack of physical activity,
  • overdose  of alcohol and cigarettes,
  • irregular lifestyle.

 

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A healthy lifestyle is able to protect us against the development of cardiovascular disease. But not only healthy lifestyle! It has been proven that incident myocardial infarction are very rare in people living in upland (Majid E. et al 2011), although often their diet is far from what we call a health food. It was based on the observation that cardioprotective (protects the heart) properties are most likely contained in the moutain atmosphere.

 

Using alpine climate properties in the treatment of cardiovascular diseases

Research on the effects of high altitude environment were initiated in Russia. Russian scientists have published many works, which have demonstrated the positive effects of high altitude hypoxia slight impact on the cardiovascular system, although its attention focused especially on the respiratory system (read more in Asthma).

Today, in many centers in the world carried out investigations on the impact of the stimulus impact of the altitude – characterized by reduced oxygen in the air – on the myocardium, which led to the creation of the term „hardening by hypoxia.” Tempering cardiac hypoxia is by reducing the oxygen content of the breathing mixture. This leads to a complex biochemical responses, which is based, inter alia, increased expression of genes inactive at normal oxygen content. For a better understanding of all the mechanisms refer to technical literature.

 

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Medical basis

In the myocardium, while staying in high altitudes, there is first of all channels for the activation of mitochondrial ATP-sensitive potassium (mitKATP). This leads to hyperpolarization of the cell membrane, which in turn results in reduced shrinkage, helping to save energy and oxygen. MitKATP efficiency is therefore important at the moment when it comes to coronary events (myocardial infarction), heart muscle better cope with the lack of oxygen. Another actuating mechanism during the session repeated to generate reactive hardening oxygen species (ROS-known as free radicals). Their appearance stimulates antioxidant enzymes to increased activity. Due to the high activity of antioxidant enzymes myocardium can effectively defend against a large amount of ROS during the attack. Reactive oxygen species are a major factor damaging the heart muscle cells, both at the time of cessation of blood flow through the coronary vessel, as well as after endarterectomy. Another positive factor for heart muscle is increased activity of hypoxia inducible factor (HIF). It has been shown that the increased activity in the myocardium significantly correlated with less surface damage after reperfusion (restoration of blood circulation in the coronary artery occlusion). Here also shows part of the vascular endothelial growth factor, namely its ability to stimulate the release of vascular endothelial larger than usual amount of nitric oxide (NO). Increased presence of nitric oxide dilates the coronary vessels, allowing blood flow through the not fully obstructed vessel. Nitric oxide also frees the hepatocyte growth factor (HGF), which has proven to be cardio-and regeneration (Kolar F. et al 2004).

This has also been shown in animal models that being under lowered oxygen content before the operations / procedures on the heart has positive effects in the form of its less damage of – subsequent myocardial condition after surgery / operation is better (Kolar F. et al 2006). At the same time stay in simulated altitude conditions may prevent cardiac arrhythmias, by stabilizing the cell membrane of cardiomyocytes (Meerson FZ. 1987).

 

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Important for the patient

LOXYS specializes in creating an atmosphere of high altitude. The conditions produced by us can be effectively carried out myocardial hardening, discussed above, making it possible to avoid a heart attack, and if it occurs will be far less severe complications. In addition, regular sessions in conditions of reduced oxygen content will improve your fitness, lower resting heart rate and normalize blood pressure. These effects can be achieved without the need for physical exercise. Passive stay also brings the results discussed so that patients desire to return to active leisure. The positive effects of the therapy have been shown both in patients with known cardiac disease, as well as in healthy individuals.

 

Important for the physician / scientist

LOXYS provides the technology to guarantee stable conditions inside the rooms. This allows you to explore and implement innovative methods of dealing with all kinds of diseases and ailments, without the risk of the emergence of confounding factors. All four requirements are met, the study puts to the type of project – maximum safety for the patient, stable and reproducible conditions for the researcher.

Studies using controlled hypoxia for several years to bring the world of science more and more solutions that change the look on a variety of issues, particularly in the field of biomedical sciences. Hypoxia appears to be not only something that should be associated with the withering away of tissue. It becomes a tool and a key to opening up a new field of action in clarifying the mechanisms of physiological, biochemical or genetic.